DEVELOPMENTAL FLUORIDE NEUROTOXICITY A SYSTEMATIC REVIEW AND META-ANALYSIS PDF

Objective: We performed a systematic review and meta-analysis of published demiological studies of developmental fluo-. ride neurotoxicity. Developmental Fluoride Neurotoxicity: Choi et al. Respond . fluoride neurotoxicity: a systematic review and meta-. analysis. Environ Health. “Developmental Fluoride Neurotoxicity: A Systematic Review and Meta-Analysis” is a study published in Environmental Health.

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Heterogeneity, however, remained at a similar magnitude when the analyses were restricted Table 2. Mental association Disease regression Epidemiology. This study was supported by internal institutional funds. Several studies Hong et al.

Effect of high fluoride water on intelligence deview school children in India. Average IQ score was lower in children in the high-fluoride group than those in the reference group.

The standardized weighted mean difference meta-analysix IQ score between exposed and reference populations was —0. Our review cannot be used to derive an exposure limit, because the actual exposures of the individual children are not known. Systematic Reviews in Health Care: Katherine Perrott Neurotoxicology and teratology Survey of drinking water quality in Jintang County.

Reference lists of included articles were also searched. Two cohorts were exposed to fluoride from coal burning Guo et al.

Developmental fluoride neurotoxicity: a systematic review and meta-analysis

Future research should formally evaluate dose—response relations based on individual-level measures of fluorjde over time, including more precise prenatal exposure assessment and more extensive standardized measures of neurobehavioral performance, in addition to improving assessment and control of potential confounders.

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Future research should include detailed individual-level information on prenatal exposure, neurobehavioral performance, and covariates for adjustment.

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Developmental Fluoride Neurotoxicity: A Systematic Review and Meta-Analysis

Four studies published in English Li XS et al. Measurement of intelligence by drawing test among the children in the endemic area of Al-F combined toxicosis. OBJECTIVE We performed a systematic review and meta-analysis of published studies to investigate the effects of increased fluoride exposure and delayed neurobehavioral development. The IQ scores of children in the high-fluoride group were significantly lower than those in the reference group.

The authors of the original meta-analysis published an updated statement on the study in September of that year, [5] underscoring this:.

Malik, Harvard School of Public Health, for the helpful advice on the meta-analysis methods.

Address correspondence to A. Fluoride may cause neurotoxicity in laboratory animals, including effects on learning and memory Chioca et al. What a ghastly thing to see coming from real scientists, doing real science! Six of the 34 studies identified were excluded because of missing information on the number of subjects or the mean and variance of the outcome [see Figure 1 for a study selection flow chart and Supplemental Material, Table S1 http: Our comprehensive review substantially extends the scope of research available for evaluation and analysis.

It is projected that all rural residents will have access to safe public drinking water by World Bank Retrieved from ” https: Policy and Institutional Considerations.

No significant difference in IQ scores between children in the exposed and reference groups. We carried out an extensive review that includes epidemiological studies carried out in China.

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Developmental Fluoride Neurotoxicity: A Systematic Review and Meta-Analysis – Semantic Scholar

Support Center Support Center. Developmental neurotoxicity of industrial chemicals. The random-effects SMD estimate was meta-analyss. Research on intelligence quotient of year-old children in a district with a high level of fluoride.

Results Six of the 34 studies identified were excluded because of missing information on the number of subjects or the mean and variance of the outcome [see Figure 1 for a study selection flow chart and Supplemental Material, Table S1 http: Open in a separate window. We noted and recorded the information on age and sex of children, and parental education and income if available. Study quality was not formally assessed but the authors noted many quality deficiencies of the studies. More recently published studies gave smaller effect sizes SMD 0.

High fluoride exposure in drinking water: From the adjusted R 2 High fluoride and low iodine environment and subclinical cretinism in Xinjiang.

In many rural communities in China, populations with high exposure to fluoride in local drinking-water sources may reside in close proximity to populations without high exposure NRC Children had lower IQ scores in high-fluoride area than those who lived in the reference area.